The comprehensive morphological and molecular characteristics of lipoastrocytoma: A case report

作者：Yuan Feng, Peter Jih Cheng Wong, Minjie Fu, Yu Kong, Hao Xu, Guo Yu, Yanwei Wu, Fufang Qiu, Zunguo Du, Tianming Qiu, Jiajun Zheng, Wei Hua · 发表于：Journal of Neuropathology & Experimental Neurology · 年份：2024 · DOI：10.1093/jnen/nlae047 · 研究领域：Sarcoma Diagnosis and Treatment、Cancer Genomics and Diagnostics、Glioma Diagnosis and Treatment

To the Editor: Lipoastrocytomas are extremely rare neuroepithelial tumors characterized by abundant lipidization resulting in an adipocyte-like appearance; they were described by Walter et al1 in 1994. To date, only 13 cases have been reported without gender or age preference. Lipoastrocytomas most commonly occur in the cerebrum,2–5 while pontine,6 and spinal cord7 cases have also been reported. The prognosis and treatment strategies for this tumor remain unclear; there is only one reported case of death associated with a pontine lipoastrocytoma that was caused by meningoencephalitis rather than tumor invasion or progression.6 Histologically, lipoastrocytomas are characterized by well-demarcated growth, eosinophilic granular bodies, and cystic change, similar morphologically to low-grade gliomas (LGG).3 Fat droplets in the tumor cells coalesce into one large droplet and push the nucleus to the periphery. The 2021 WHO classification of central nervous system (CNS) tumors emphasized the role of molecular alterations on glioma subtypes.8 DNA methylome analysis offers another tool for precise classification.9 Although described as a variant of LGG, whether lipoastrocytomas share the same molecular characteristics as LGG has not been confirmed.10 Therefore, investigating the molecular map of lipoastrocytomas may help to clarify the mechanism of lipidization and explore the potential treatment. Here, we report a case of lipoastrocytoma occurring at the anterior corpus callosum. Imm...