Synthesis of novel silver-loaded clay AgF@Hec for the prevention of dental caries in vitro

作者：Yuansheng Wang, Y X Shi, Qinqin Liu, Liqun Hu, Fathollah Zadeh B., J R Zhang, Ke Tang, Bin Tang, Juan Dai · 发表于：Biomedical Materials · 年份：2024 · DOI：10.1088/1748-605x/ad51c1 · 被引用次数：1 · 研究领域：Oral microbiology and periodontitis research、Dental Erosion and Treatment、Bone Tissue Engineering Materials

Abstract Dental caries, a chronic infectious disease characterized by tooth mineral loss caused by plaque, is one of the major global public health problems. Silver diamine fluoride (SDF) has been proven to be a highly effective anti-caries drug due to its high bacterial inhibition and remineralization ability. However, the SDF solution is unstable, which immensely limits its clinical application. Therefore, new silver-load clay named AgF@Hec was designed by replacing the NH 3 with hectorite in this study. Fourier transform infrared spectroscopy and x-ray diffraction spectroscopy were employed to confirm the structure of AgF@Hec. Dynamic light scattering analysis was used to reveal the effect of different hectorite concentrations on the stability of AgF@Hec. Moreover, AgF@Hec exhibits significant remineralization and hardness recovery of the initial carious lesions. Bacteriostatic experiments also proved that it has a significant inhibitory effect on A. Viscosus, S. mutans, S. sanguinis, S. salivarius, Lactobacillus sp. and both gram-positive and gram-negative bacteria. We therefore believed that AgF@Hec should be a promising biomaterial that can be applied in the prevention of dental caries.