Correlation between the miR‐618 rs2682818 C>A polymorphism and venous malformation susceptibility

作者：Xi Lin, Zijian Chen, Guitao Wu, Hua Jiang, Zhenyin Liu · 发表于：Biotechnology and Applied Biochemistry · 年份：2024 · DOI：10.1002/bab.2618 · 被引用次数：1 · 研究领域：Vascular Malformations and Hemangiomas、Tumors and Oncological Cases、Vascular Malformations Diagnosis and Treatment

Venous malformations are the most common congenital vascular malformations, and the incidence rate is high. Previous studies have confirmed that a variety of polymorphisms within the miRNA functional region are associated with tumor susceptibility. We examined the correlation between miR-618 rs2682818 C>A and risk of developing venous malformation in a southern Chinese population (1113 patients and 1158 controls). TaqMan genotyping of miR-618 rs2682818 C>A was conducted utilizing real-time fluorescent quantitative PCR. The miR-618 rs2682818 polymorphism was not correlated with susceptibility to venous malformation (CA/AA vs. CC: adjusted odds ratio [AOR] = 1.00, 95% confidence interval [CI] = 0.81-1.25, p = 0.994; AA vs. CC/CA: AOR = 1.10, 95% CI = 0.73-1.65, p = 0.646). Stratified analysis of different subtypes of venous malformation revealed that there was no significant difference in the rs2682818 C>A polymorphism genotypes across these subtypes. Our results indicate that miR-618 rs2682818 C>A polymorphism is not correlated with the susceptibility to venous malformation.