Zn-Mediated Fragmentation of N-Alkoxyphthalimides Enabling the Synthesis of gem-Difluoroalkenes

作者：Yiyue Wang, Wei-Jun Pang, Tie Liu, Jing Sun, Mingdong Zhou · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c01433 · 被引用次数：11 · 研究领域：Fluorine in Organic Chemistry、Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms

Zn-mediated generation of alkoxyl radicals from N -alkoxyphthalimides emerged as an efficient approach for forming diverse and valuable alkyl radicals through β-scission or a hydrogen atom transfer process. The alkyl radical species can be further trapped by α-trifluoromethyl alkenes to construct a series of gem -difluoroalkenes.