Protective effects of l -theanine and dihydromyricetin on reproductive function in male mice under heat stress

作者：D. Yang, Kaihang Xu, Wenmao Wang, Peijian Chen, Chao Liu, Sha Liu, Wei Xu, Wenjun Xiao · 发表于：Food & Function · 年份：2024 · DOI：10.1039/d4fo00208c · 被引用次数：11 · 研究领域：Medicinal plant effects and applications、Biological Activity of Diterpenoids and Biflavonoids、Natural product bioactivities and synthesis

showed the best protective effect. The potential mechanism involves the regulation of HSP27 and HSP70, which regulate the levels of reproductive hormones through the StAR/Cyp11a1/Hsd3b1/Cyp17a1/Hsd17b3 pathway, alleviate inflammation and oxidative stress through the P38/NF-κB/Nrf2/HO-1 pathway, and regulate the Bcl-2/Fas/Caspase3 apoptotic pathway. Overall, L-theanine and dihydromyricetin may play a protective role against heat stress-induced reproductive dysfunction, suggesting their potential use in heat stress-resistant foods.