Mechanisms and recent advances in the diagnosis and treatment of nitrous oxide-induced peripheral neuropathy: a narrative review

作者：Xiaodi Zou, Fangyu Yi, Weijie Zhou, Yanzhao Dong, Ahmad Alhaskawi, Haiying Zhou, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Olga Alenikova, Sahar Ahmed Abdalbary, Hui Lü, Wang Changxin · 发表于：Frontiers in Neurology · 年份：2024 · DOI：10.3389/fneur.2024.1381938 · 被引用次数：8 · 研究领域：Advanced MRI Techniques and Applications、Nitric Oxide and Endothelin Effects、Takotsubo Cardiomyopathy and Associated Phenomena

Under standard conditions, nitrous oxide (N 2 O) manifests as a colorless, odorless gas with a mildly sweet taste. The compound finds applications in various fields, including its use as an aerosol propellants, an accelerant in motor racing, and an anesthetic in surgical procedures and dentistry. Unfortunately, the recreational misuse of N 2 O has become prevalent among young individuals due to its euphoric and hallucinogenic effects. Compounding this issue is the fact that nitrous oxide can be easily obtained from over-the-counter household items, facilitating its non-medical use. The global community has witnessed a surge in the recreational utilization of nitrous oxide gas in recent years. Despite the widespread non-medical abuse of N 2 O, there remains inadequate understanding of the potential adverse effects resulting from exposure to it. This paper provides an overview of management findings, laboratory and electrodiagnostic characteristics, as well as clinical presentations associated with neurological disorders induced by nitrous oxide usage.