#2276 Blood stream infections in patients with ANCA-associated vasculitis—a Danish nationwide study

作者：Nanna Thuesen Bruun, Nicholas Carlson, Mads Hornum, Emil Loldrup Fosbøl, Lauge Lauge, Marianne Volstedlund, Casper Rydahl, Per Ivarsen, Jon Waarst Gregersen, Martin Egfjord, Wladimir Szpirt, Karl Emil Nelveg-Kristensen · 发表于：Nephrology Dialysis Transplantation · 年份：2024 · DOI：10.1093/ndt/gfae069.408 · 研究领域：Vasculitis and related conditions、Antiplatelet Therapy and Cardiovascular Diseases、Heparin-Induced Thrombocytopenia and Thrombosis

Abstract Background and Aims Infection due to the immunosuppressive treatment, is among the most frequent causes of hospitalization and death in patients with ANCA-associated vasculitis (AAV). Information on prevailing causal microbial aetiologies is crucial for improving treatment and prevention of such events. Here we examined causal bacteriology, incidence, and risk of blood stream infections (BSIs) in incident and prevalent AAV patients, as compared to the general population. Method All data were retrieved from the Danish nationwide registries and the Danish Microbiology Database. Prevalent patients between 1998-2010 were all included at the same index date 1.1.2010; Incident patients diagnosed after 2010 were included with index being the day of diagnosis. Both groups were followed until first time BSI, death, or a maximum of 12 months. Background controls were matched 1:4 on age and sex. Cumulative incidence was assessed by the Aalen-Johansen estimator, and cox analyses adjusted for age, sex, kidney involvement, hypertension, diabetes, dialysis, and plasma exchange (PLEX), were used to model survival time. Results A total 19 (2.3%) BSIs were identified in 818 prevalent patients, and 55 (5.9%) BSIs in 939 incident patients (P < 0.001). As in the background control group, primary causal microbial agents among prevalent patients were E. coli (26.3%) and S. aureus (21.1%), with an overall Gram-negative predominance (58.8%). E. coli (17.5%) remained the most frequent ...