Diastereoselective dearomatization of indoles via photocatalytic hydroboration on hydramine-functionalized carbon nitride

作者：Qiao Zhang, Wengang Xu, Qiong Liu, Congjian Xia, Qi Shao, Lishuang Ma, Mingbo Wu · 发表于：Nature Communications · 年份：2024 · DOI：10.1038/s41467-024-48769-1 · 被引用次数：26 · 研究领域：Radical Photochemical Reactions、Advanced Photocatalysis Techniques、Sulfur-Based Synthesis Techniques

A protocol for trans-hydroboration of indole derivatives using heterogeneous photocatalysis with NHC-borane has been developed, addressing a persistent challenge in organic synthesis. The protocol, leveraging high crystalline vacancy-engineered polymeric carbon nitride as a catalyst, enables diastereoselective synthesis, expanding substrate scope and complementing existing methods. The approach emphasizes eco-friendliness, cost-effectiveness, and scalability, making it suitable for industrial applications, particularly in renewable energy contexts. The catalyst's superior performance, attributed to its rich carbon-vacancies and well-ordered structure, surpasses more expensive homogeneous alternatives, enhancing viability for large-scale use. This innovation holds promise for synthesizing bioactive compounds and materials relevant to medicinal chemistry and beyond.