ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies

作者：Fang-Hua Liu, Jia-Kai Guo, Wei-Yi Xing, Xueli Bai, Yu-Jiao Chang, Lu Zhao, Miao Yang, Ying Yang, Wenjing Li, Xianxian Jia, Tao Zhang, Jing Yang, Jun‐Tong Chen, Song Gao, Lang Wu, Deyu Zhang, Chuan Liu, Ting‐Ting Gong, Qi‐Jun Wu · 发表于：BMC Medicine · 年份：2024 · DOI：10.1186/s12916-024-03423-x · 被引用次数：16 · 研究领域：Blood groups and transfusion、Blood transfusion and management、Neonatal Health and Biochemistry

Abstract Background Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associations is still lacking. Methods We searched PubMed, Web of Science, Embase, Scopus, Cochrane, and several regional databases from their inception until Feb 16, 2024, with the aim of identifying systematic reviews with meta-analyses of observational studies exploring associations between ABO and Rh blood groups and diverse health outcomes. For each association, we calculated the summary effect sizes, corresponding 95% confidence intervals, 95% prediction interval, heterogeneity, small-study effect, and evaluation of excess significance bias. The evidence was evaluated on a grading scale that ranged from convincing (Class I) to weak (Class IV). We assessed the certainty of evidence according to the Grading of Recommendations Assessment, Development, and Evaluation criteria (GRADE). We also evaluated the methodological quality of included studies using the A Measurement Tool to Assess Systematic Reviews (AMSTAR). AMSTAR contains 11 items, which were scored as high (8–11), moderate (4–7), and low (0–3) quality. We have gotten the registration for protocol on the PROSPERO database (CRD42023409547). Results The current umbrella review included 51 systematic reviews with meta-analysis articles with 270 associations. We re-calculated each association and foun...