Clinical features and risk factors for pyogenic liver abscess caused by multidrug-resistant organisms: A retrospective study

作者：Qin Long, Xiaoyu Zhao, Chang Chen, Min Hao, X. P. Qin · 发表于：Virulence · 年份：2024 · DOI：10.1080/21505594.2024.2356680 · 被引用次数：14 · 研究领域：Amoebic Infections and Treatments、Gallbladder and Bile Duct Disorders、Diagnosis and treatment of tuberculosis

The incidence rate of pyogenic liver abscess caused by multidrug-resistant bacteria has increased in recent years.This study aimed to identify the clinical characteristics and risk factors for pyogenic liver abscess caused by multidrug-resistant bacteria.We conducted a retrospective analysis of the clinical features, laboratory test results, and causes of pyogenic liver abscesses in 239 patients admitted to a tertiary hospital.Multivariable logistic regression was used to identify risk factors for multidrug resistance.Among patients with pyogenic liver abscesses, the rate of infection caused by multidrug-resistant organisms was observed to be 23.0%(55/239), with a polymicrobial infection rate of 14.6% (35/239).Additionally, 71 cases (29.7%) were associated with biliary tract disease.Patients with pyogenic liver abscesses caused by multidrug-resistant organisms had a significantly higher likelihood of polymicrobial infection and increased mortality (7/44 [15.9%] vs. 3/131 [2.3%]; p = .003).The Charlson Comorbidity Index (adjusted odds ratio [aOR]: 1.32, 95% confidence interval [CI]: 1.06-1.68),hospitalization (aOR: 10.34, 95% CI: 1.86-60.3)or an invasive procedure (aOR: 9.62; 95% CI: 1.66-71.7)within the past 6 months, and gas in the liver on imaging (aOR: 26.0; 95% CI: 3.29-261.3)were independent risk factors for pyogenic liver abscess caused by multidrug-resistant bacteria.A nomogram was constructed based on the risk factors identified.The nomogram showed high diagnostic acc...