Association of fetal fraction and cell‐free fetal DNA with adverse pregnancy outcomes: A systematic review

作者：Yixin Chen, Chun Wang, Yonghong Wang, Xin Peng, Rujing Li, F. Maceiras Pan · 发表于：International Journal of Gynecology & Obstetrics · 年份：2024 · DOI：10.1002/ijgo.15612 · 被引用次数：7 · 研究领域：Prenatal Screening and Diagnostics、Pregnancy and preeclampsia studies、Fetal and Pediatric Neurological Disorders

BACKGROUND: Adverse pregnancy outcomes, which can be caused by multiple factors, present a significant threat to the health of mothers and their babies. Cell-free fetal DNA (cffDNA) from placental trophoblast cells might be able to reflect placental and fetal status. Previous studies have yielded controversial results regarding the association of FF or cffDNA with various adverse pregnancy outcomes. A previous study has attempted to systematically assess the association between low fetal fraction (FF) and adverse pregnancy outcomes, but it failed to perform quantitative analyses due to the few studies included. In the present study, we attempted to quantitatively assess the association of FF (or cffDNA) with adverse pregnancy outcomes and further analyze the causes of heterogeneity. OBJECTIVES: To investigate the association of high/low FF or cffDNA with adverse pregnancy outcomes. SEARCH STRATEGY: We searched the databases of PubMed, Embase, Cochrane, and Web of Science from January 1, 1990, to June 15, 2022 in this meta-analysis. SELECTION CRITERIA: Studies on the relationships of adverse pregnancy outcomes in women with FF or cell free DNA were included. Non-English literature was excluded. DATA COLLECTION AND ANALYSIS: Data about pregnancy outcomes and cell free DNA were extracted and meta-analyzed. Subgroup analysis was performed by different outcomes. MAIN RESULTS: = 27%, 25%), and a fixed-effect model was used for weighted quantitative analysis. The results revealed th...