Comparison of clinical outcomes in hospitalized patients with COVID-19 or non-COVID-19 community-acquired pneumonia in a prospective observational cohort study

作者：Hans-Jakob Meyer, Lukas Mödl, Olesya Unruh, Weiwei Xiang, Sarah Berger, Moritz Müller-Plathe, Gernot Rohde, Mathias W. Pletz, Jan Rupp, Norbert Suttorp, Martin Witzenrath, Thomas Zöller, Mirja Mittermaier, Fridolin Steinbeis, CAPNETZ study group, André Fuchs, Michael Engelmann, Daiana Stolz, Wolfgang Bauer, H.C. Mücke, Sibylle Schmager, Bernhard Schaaf, Julius Kremling, Daniela Nickoleit-Bitzenberger, Harun Azzaui, Martin Hower, F. Hempel, Katharina Prebeg, Kalina Popkirova, Martin Kolditz, Carla Bellinghausen, A Grünewaldt, Marcus Panning, Tobias Welte, T Fühner, Maryse van’t Klooster, Grit Barten-Neiner, W. Kröner, Nina Adaskina, F. Eberherdt, Christina Julius, Thomas Illig, N. Klopp, Benjamin T. Schleenvoigt, Christina Forstner, Anne Moeser, Juliane Ankert, Daniel Drömann, P Parschke, Klaas Franzen, Nadja Käding, Frederike Waldeck, Christoph D. Spinner, Johanna Erber, Florian Voit, Jochen Schneider, David F. Heigener, I. Hering, Werner C. Albrich, Marco Seneghini, Frank Rassouli, S. Baldesberger, A. Essig, Steffen Stenger, M. Wallner, Heinz Burgmann, Ludwig Traby, Lorenz Schubert, Ruoling Chen · 发表于：Infection · 年份：2024 · DOI：10.1007/s15010-024-02292-z · 被引用次数：5 · 研究领域：Pneumonia and Respiratory Infections、COVID-19 Clinical Research Studies、Nosocomial Infections in ICU

PURPOSE: Coronavirus disease 2019 (COVID-19) and non-COVID-19 community-acquired pneumonia (NC-CAP) often result in hospitalization with considerable risks of mortality, ICU treatment, and long-term morbidity. A comparative analysis of clinical outcomes in COVID-19 CAP (C-CAP) and NC-CAP may improve clinical management. METHODS: Using prospectively collected CAPNETZ study data (January 2017 to June 2021, 35 study centers), we conducted a comprehensive analysis of clinical outcomes including in-hospital death, ICU treatment, length of hospital stay (LOHS), 180-day survival, and post-discharge re-hospitalization rate. Logistic regression models were used to examine group differences between C-CAP and NC-CAP patients and associations with patient demography, recruitment period, comorbidity, and treatment. RESULTS: Among 1368 patients (C-CAP: n = 344; NC-CAP: n = 1024), C-CAP showed elevated adjusted probabilities for in-hospital death (aOR 4.48 [95% CI 2.38-8.53]) and ICU treatment (aOR 8.08 [95% CI 5.31-12.52]) compared to NC-CAP. C-CAP patients were at increased risk of LOHS over seven days (aOR 1.88 [95% CI 1.47-2.42]). Although ICU patients had similar in-hospital mortality risk, C-CAP was associated with length of ICU stay over seven days (aOR 3.59 [95% CI 1.65-8.38]). Recruitment period influenced outcomes in C-CAP but not in NC-CAP. During follow-up, C-CAP was linked to a reduced risk of re-hospitalization and mortality post-discharge (aOR 0.43 [95% CI 0.27-0.70]). CONCLU...