Role of m6A modifications in immune evasion and immunotherapy

作者：Chunyu Wu, Lvyuan Li, Qiling Tang, Qianjin Liao, Pan Chen, Can Guo, Zhaoyang Zeng, Wei Xiong · 发表于：Medical Oncology · 年份：2024 · DOI：10.1007/s12032-024-02402-9 · 被引用次数：10 · 研究领域：RNA modifications and cancer、HVDC Systems and Fault Protection、Peptidase Inhibition and Analysis

RNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune surveillance. N 6 -methyladenosine (m 6 A) modification is the most prevalent RNA modification, which can affect the expression of RNA by methylating adenylate at the sixth N position to regulate the occurrence and development of tumors. Dysregulation of m 6 A affects the activation of cancer-promoting pathways, destroys immune cell function, maintains immunosuppressive microenvironment, and promotes tumor cell growth. In this review, we delve into the latest insights into how abnormalities in m 6 A modification in both tumor and immune cells orchestrate immune evasion through the activation of signaling pathways. Furthermore, we explore how dysregulated m 6 A modification in tumor cells influences immune cells, thereby regulating tumor immune evasion via interactions within the tumor microenvironment (TME). Lastly, we highlight recent discoveries regarding specific inhibitors of m 6 A modulators and the encapsulation of m 6 A-targeting nanomaterials for cancer therapy, discussing their potential applications in immunotherapy.