Emergence of Erythromycin-Resistant and Pertactin- and Filamentous Hemagglutinin-Deficient <i>Bordetella pertussis</i> Strains — Beijing, China, 2022–2023

作者：Guilan Zhou, Ying Li, Hairui Wang, Yuanyuan Wang, Yuan Gao, Juan Xu, Fengshuang Wang, Tao Peng, Maojun Zhang, Zhujun Shao · 发表于：China CDC Weekly · 年份：2024 · DOI：10.46234/ccdcw2024.085 · 被引用次数：22 · 研究领域：Bacterial Infections and Vaccines、Pneumonia and Respiratory Infections、RNA and protein synthesis mechanisms

What is already known about this topic? Pertussis has reemerged as a significant public health threat, primarily due to variations in Bordetella pertussis strains, antimicrobial resistance, and vaccine evasion. What is added by this report? All isolated strains were identified as ptxA1/ptxC2/ptxP3/prn150/fim2-1/fim3-1/fhaB1/tcfA2 type and exhibited resistance to erythromycin. Two strains showed a deficiency in Fha, thirty in Prn, and one strain exhibited multiple immunogen deficiencies. What are the implications for public health practice? The emergence and spread of immunogen-deficient strains likely result from prolonged vaccine selection pressure, posing challenges to the efficacy of pertussis vaccines. Additionally, the ongoing dissemination of ptxP3 strains with high-level macrolide resistance presents a significant obstacle to clinical treatment strategies.