Fluorescent Probes for Disease Diagnosis

作者：Xin Wang, Qi Ding, Robin R. Groleau, Luling Wu, Yuantao Mao, Feida Che, Oxana Kotova, Eoin M. Scanlan, Simon E. Lewis, Ping Li, Bo Tang, Tony D. James, Thorfinnur Gunnlaugsson · 发表于：Chemical Reviews · 年份：2024 · DOI：10.1021/acs.chemrev.3c00776 · 被引用次数：506 · 研究领域：Nanoplatforms for cancer theranostics、Advanced biosensing and bioanalysis techniques、Molecular Sensors and Ion Detection

. In this review, we describe current fluorescent probes designed for the detection and quantification of key bioactive molecules associated with common diseases, such as organ damage, inflammation, cancers, cardiovascular diseases, and brain disorders. We emphasize the strategies behind the design of fluorescent probes capable of disease biomarker detection and diagnosis and cover some aspects of combined diagnostic/therapeutic strategies based on regulating disease-related molecules. This review concludes with a discussion of the challenges and outlook for fluorescent probes, highlighting future avenues of research that should enable these probes to achieve accurate detection and identification of disease-related biomarkers for biomedical research and clinical applications.