Development of Configurationally Labile Biaryl Reagents for Atropisomer Synthesis

作者：Changhui Wu, Jin Yang, Xiaoyuan Zhang, Ruiqi Gao, Xiaowei Dou · 发表于：European Journal of Organic Chemistry · 年份：2024 · DOI：10.1002/ejoc.202400402 · 被引用次数：17 · 研究领域：Axial and Atropisomeric Chirality Synthesis、Molecular spectroscopy and chirality、Chemical synthesis and alkaloids

Abstract Axially chiral biaryl scaffolds are important in pharmaceuticals, natural products, and asymmetric synthesis. Atroposelective ring‐opening of configurationally labile biaryl reagents via dynamic kinetic asymmetric transformation provides a valuable approach to access axially chiral biaryl atropisomers. This review summarizes seminal contributions and recent advancements on this topic based on the use of different types of configurationally labile biaryl reagents.