Association between pediatric postoperative delirium and regional cerebral oxygen saturation: a prospective observational study

作者：Kexian Liu, Nan Lin, Ting Jin, Yujun Xiang, Jiahuan Li, Dengming Lai, Hongzhen Xu · 发表于：BMC Psychiatry · 年份：2024 · DOI：10.1186/s12888-024-05832-x · 被引用次数：6 · 研究领域：Intensive Care Unit Cognitive Disorders、Anesthesia and Neurotoxicity Research、Anesthesia and Sedative Agents

Abstract Background Postoperative delirium (POD) represents a prevalent and noteworthy complication in the context of pediatric surgical interventions. In recent times, a hypothesis has emerged positing that cerebral ischemia and regional cerebral oxygen desaturation might serve as potential catalysts in the pathogenesis of POD. The primary aim of this study was to methodically examine the potential relationship between POD and regional cerebral oxygen saturation (rSO 2 ) and to assess the predictive and evaluative utility of rSO 2 in the context of POD. Methods This prospective observational study was conducted at the Children’s Hospital, Zhejiang University School of Medicine, Zhejiang, China, spanning the period from November 2020 to March 2021. The research cohort comprised children undergoing surgical procedures within this clinical setting. To measure rSO 2 dynamics, cerebral near-infrared spectroscopy (NIRS) was used to monitor rSO 2 levels both before and after surgery. In addition, POD was assessed in the paediatric patients according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) criteria. The analysis of the association between the rSO 2 index and the incidence of POD was carried out through the application of either the independent samples t-test or the nonparametric rank-sum test. To ascertain the threshold value of the adjusted rSO 2 index for predictive and evaluative purposes regarding POD in the pediatric population, the Re...