A Wireless Subdural Optical Cortical Interface Device with 768 Co-Packaged Micro-LEDs for Fluorescence Imaging and Optogenetic Stimulation

作者：Yatin Gilhotra, Henry Overhauser, Heyu Yin, Eric H. Pollmann, Guy Eichler, A. F. Cheng, Tae‐Sung Jung, Nanyu Zeng, Luca P. Carloni, Kenneth L. Shepard · 年份：2024 · DOI：10.1109/cicc60959.2024.10529077 · 被引用次数：4 · 研究领域：Photoreceptor and optogenetics research、Molecular Communication and Nanonetworks、Neuroscience and Neural Engineering

One of the goals of neuroengineering is to establish high-bandwidth, fully implantable, and minimally invasive wireless neural interfaces that help interrogate neural circuits in freely moving and socially behaving animals. Optical interfaces offer advantages over electrophysiological techniques such as cell-type specificity, low cross-talk bidirectionality, and wide field-of-view (FoV). While most optical interfaces to-date have taken the form of bulky “mini-scopes”, recent advances in optical interfaces have shown promise in achieving high-resolution, volume-efficient brain interfacing over large FoVs with devices accommodated entirely within the subdural space [1], [2]. These devices, however, still require wired connection through the skull, negating advantages of their volumetric efficiency. We introduce a fully wireless, 12x12 mm2subdural optical interface with a 5.76x7.68 mm2FoV for lens-less imaging and optogenetic stimulation. The FoV can span multiple brain regions in non-human primates, enabling brain coordination studies with unprecedented detail. The device features monolithically integrated single-photon avalanche diodes (SPADs) in a 192x256 array with a pitch of 30μm for fluorescence imaging, complemented by an integrated array of 24x32 micro-LEDs (μLEDs) with 240μm pitch for fluorescent excitation and optogenetic stimulation. A hybrid emission filter, an excitation filter, and a computational imaging mask complete the packaging stack-up as shown in Fig. 1. The...