Mechanisms of epigallocatechin gallate (EGCG) in ameliorating hyperuricemia: insights into gut microbiota and intestinal function in a mouse model

作者：Haonan Yu, Zhenyou Lou, Tingbo Wu, Xiaochun Wan, Haitao Huang, Yuanyuan Wu, Bo Li, Youying Tu, Puming He, Junsheng Liu · 发表于：Food & Function · 年份：2024 · DOI：10.1039/d4fo01606h · 被引用次数：22 · 研究领域：Gout, Hyperuricemia, Uric Acid、Exercise and Physiological Responses、Pharmacological Effects of Natural Compounds

, which displayed high correlations with serum UA levels and UA-related gene expression. Metabolomic analysis suggested that EGCG-induced modifications in bacterial metabolites might contribute to the alleviation of hyperuricemia. Transcriptomic analysis of the intestinal epithelium identifies 191 differentially expressed genes (DEGs) in EGCG-treated mice, including 8 purine-related genes. This study elucidates the anti-hyperuricemic mechanisms of EGCG, particularly its influence on the gut microbiota and gene expression in the intestinal epithelium.