Investigation of the Link between Per- and Polyfluoroalkyl Substances and Stress Biomarkers in Bottlenose Dolphins ( Tursiops truncatus )

作者：Baylin Bennett, Max T. Aung, Rudy Boonstra, Brendan Delehanty, Magali Houde, Derek C. G. Muir, Patricia A. Fair, Matthew O. Gribble · 发表于：Environmental Science & Technology · 年份：2024 · DOI：10.1021/acs.est.3c06979 · 被引用次数：10 · 研究领域：Per- and polyfluoroalkyl substances research、Atmospheric Ozone and Climate、Atmospheric chemistry and aerosols

High Resolution Image Download MS PowerPoint Slide Bottlenose dolphins ( Tursiops truncatus ) are keystone and sentinel species in the world’s oceans. We studied correlations between per- and polyfluoroalkyl substances (PFAS) and their stress axis. We investigated associations between plasma biomarkers of 12 different PFAS variants and three cortisol pools (total, bound, and free) in wild T. truncatus from estuarine waters of Charleston, South Carolina ( n = 115) and Indian River Lagoon, Florida ( n = 178) from 2003 to 2006, 2010–2013, and 2015. All PFAS and total cortisol levels for these dolphins were previously reported; bound cortisol levels and free cortisol calculations have not been previously reported. We tested null hypotheses that levels of each PFAS were not correlated with those of each cortisol pool. Free cortisol levels were lower when PFOS, PFOA, and PFHxS biomarker levels were higher, but free cortisol levels were higher when PFTriA was higher. Bound cortisol levels were higher when there were higher PFDA, PFDoDA, PFDS, PFTeA, and PFUnDA biomarkers. Total cortisol was higher when PFOA was lower, but total cortisol was higher when PFDA, PFDoDA, PFTeA, and PFTriA were higher. Additional analyses indicated sex and age trends, as well as heterogeneity of effects from the covariates carbon chain length and PFAS class. Although this is a cross-sectional observational study and, therefore, could reflect cortisol impacts on PFAS toxicokinetics, these correlations are ...