Harnessing clonal gametes in hybrid crops to engineer polyploid genomes

作者：Yazhong Wang, Roven Rommel Fuentes, Willem M. J. van Rengs, Sieglinde Effgen, Mohd Waznul Adly Mohd Zaidan, Rainer Franzen, Tamara Susanto, Joiselle Blanche Fernandes, Raphaël Mercier, Charles J. Underwood · 发表于：Nature Genetics · 年份：2024 · DOI：10.1038/s41588-024-01750-6 · 被引用次数：61 · 研究领域：Chromosomal and Genetic Variations、Plant Virus Research Studies、Plant Reproductive Biology

Heterosis boosts crop yield; however, harnessing additional progressive heterosis in polyploids is challenging for breeders. We bioengineered a 'mitosis instead of meiosis' (MiMe) system that generates unreduced, clonal gametes in three hybrid tomato genotypes and used it to establish polyploid genome design. Through the hybridization of MiMe hybrids, we generated '4-haplotype' plants that encompassed the complete genetics of their four inbred grandparents, providing a blueprint for exploiting polyploidy in crops.