Analysis of multiple factors influencing the survival of patients with advanced gastric cancer

作者：Xinqiang Zhu, Beibei Ge, Linchun Wen, Hailong Huang, Xiaohong Shi · 发表于：Aging · 年份：2024 · DOI：10.18632/aging.205820 · 被引用次数：6 · 研究领域：Gastric Cancer Management and Outcomes、Gastrointestinal Tumor Research and Treatment、Metastasis and carcinoma case studies

Objective: The aim of this study was to investigate the main factors influencing the survival of patients with advanced gastric cancer. Methods: The clinicopathological data of 120 patients with advanced gastric cancer were analyzed retrospectively, and clinical and pathological data were collected. Tumor tissue staging and grading were re-evaluated, and 5-year overall survival was followed up. The classified data were described by percentages, and the continuous data were described by standard deviations or medians. Univariate analysis was performed using the χ2 test or rank-sum test, followed by Kaplan-Meier survival analysis to calculate the median survival time and 5-year cumulative survival. A multivariate Cox regression model was used to evaluate the independent risk factors affecting survival. The test level was α = 0.05. Results: Patients were followed up for 0 to 60 months, the 5-year overall survival rate was 36.2%, and the median survival time was 53.0 ± 1.461 months. K-M and log-rank test results revealed that tumor location, degree of differentiation, depth of invasion, regional lymph node involvement, and postoperative tumor stage were correlated with a decreased 5-year survival rate (P < 0.05). A multivariate Cox risk regression model was used to analyze the degree of histological differentiation (HR = 1.441; 95% CI = 1.049–1.979; P = 0.024), regional lymph node (HR = 1.626; 95% CI = 1.160–2.279; P = 0.005), and pTNM stage (HR = 2.266; 95% CI = 1.335-3.8...