The mitigative role of novel aflatoxin‐degrading enzymes in diverse broiler performance indicators and gut microbiota following the consumption of diets contaminated with aflatoxins

作者：Ru Jia, Senmiao Tian, Zhaofeng Yang, Simeng Lu, Lan Wang, Guohua Zhang · 发表于：Journal of the Science of Food and Agriculture · 年份：2024 · DOI：10.1002/jsfa.13564 · 被引用次数：3 · 研究领域：Mycotoxins in Agriculture and Food、Animal Nutrition and Physiology、Insect and Pesticide Research

Abstract BACKGROUND This study aims to explore both the toxic effects of aflatoxins (AFs) and the protective effects of degrading enzymes (DE) on broilers exposed to AFs. RESULTS The findings reveal that a diet contaminated with 69.15 μg kg −1 of aflatoxin B 1 had significant adverse effects on broilers. Specifically, it led to a reduction in average daily gain, dressed yield percentage, half‐eviscerated yield with giblet yield percentage, eviscerated yield percentage, as well as serum superoxide dismutase (SOD), glutathione peroxidase activity and liver SOD activity ( P < 0.05). Conversely, the diet increased the feed conversion ratio, liver index, serum glutamic oxaloacetic transaminase levels and malondialdehyde levels in both serum and liver ( P < 0.05). Additionally, AFs disrupted the intestinal microflora significantly ( P < 0.05), altering the relative abundance of Enterococcus , Lactobacillus and Escherichia in broiler jejunum. The addition of DE to AF‐contaminated feed mitigated these negative effects and reduced the residues of aflatoxin B 1 , aflatoxin B 2 and aflatoxin M 1 in the liver and duodenum ( P < 0.05). We also observed that broilers fed the diet pelleted at 80 °C exhibited improved dressing percentage and water holding capacity compared to those on the 75 °C diet. CONCLUSION In summary, DE serves as an effective feed additive for mitigating AF contamination in poultry production. © 2024 Society of Chemical Industry.