Impact of treatment interval between neoadjuvant immunochemotherapy and surgery in lung squamous cell carcinoma

作者：Chen Gu, Xiao Teng, Xuqi Sun, Jia-Cong Liu, Ziyue Zhu, Lichen Zhang, Zhigang Wu, Rui Zou, Jinghua Pang, Xiayi Lyu · 发表于：BMC Cancer · 年份：2024 · DOI：10.1186/s12885-024-12333-3 · 被引用次数：5 · 研究领域：Lung Cancer Diagnosis and Treatment、Lung Cancer Research Studies、Lung Cancer Treatments and Mutations

OBJECTIVE: The optimal timing for surgery following neoadjuvant immunochemotherapy for lung squamous cell carcinoma appears to be a topic of limited data. Many clinical studies lack stringent guidelines regarding this timing. The objective of this study is to explore the effect of the interval between neoadjuvant immunochemotherapy and surgery on survival outcomes in patients with lung squamous cell carcinoma. METHODS: This study conducted a retrospective analysis of patients with lung squamous cell carcinoma who underwent neoadjuvant immunochemotherapy between January 2019 and October 2022 at The First Affiliated Hospital, Zhejiang University School of Medicine. Patients were divided into two groups based on the treatment interval: ≤33 days and > 33 days. The primary observational endpoints of the study were Disease-Free Survival (DFS) and Overall Survival (OS). Secondary observational endpoints included Objective response rate (ORR), Major Pathological Response (MPR), and Pathological Complete Remission (pCR). RESULTS: Using the Kaplan-Meier methods, the ≤ 33d group demonstrated a superior DFS curve compared to the > 33d group (p = 0.0015). The median DFS for the two groups was 952 days and 590 days, respectively. There was no statistical difference in the OS curves between the groups (p = 0.66), and the median OS was not reached for either group. The treatment interval did not influence the pathologic response of the tumor or lymph nodes. CONCLUSIONS: The study observed th...