Association of histone modification with the development of schizophrenia

作者：Yun-zhou Chen, Xiu-mei Zhu, Peng Lv, Xi-kai Hou, Ying Pan, Ang Li, Zhe Du, Jin‐feng Xuan, Xiaochong Guo, Jiaxin Xing, K. D. Liu, Jun Yao · 发表于：Biomedicine & Pharmacotherapy · 年份：2024 · DOI：10.1016/j.biopha.2024.116747 · 被引用次数：17 · 研究领域：Epigenetics and DNA Methylation、Genetics and Neurodevelopmental Disorders、HIV Research and Treatment

Schizophrenia, influenced by genetic and environmental factors, may involve epigenetic alterations, notably histone modifications, in its pathogenesis. This review summarizes various histone modifications including acetylation, methylation, phosphorylation, ubiquitination, serotonylation, lactylation, palmitoylation, and dopaminylation, and their implications in schizophrenia. Current research predominantly focuses on histone acetylation and methylation, though other modifications also play significant roles. These modifications are crucial in regulating transcription through chromatin remodeling, which is vital for understanding schizophrenia's development. For instance, histone acetylation enhances transcriptional efficiency by loosening chromatin, while increased histone methyltransferase activity on H3K9 and altered histone phosphorylation, which reduces DNA affinity and destabilizes chromatin structure, are significant markers of schizophrenia.