Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study

作者：Yimiao Zhao, Qiongdan Liang, Zhendong Jiang, Huan Mei, Na Zeng, Sizhen Su, Shanshan Wu, Yinghong Ge, Peng Li, Xiao Lin, Kai Yuan, Le Shi, Wei Yan, Xiaoxing Liu, Jie Sun, Weijian Liu, Guido van Wingen, Yujun Gao, Yiqing Tan, Yi Hong, Yu Lu, Ping Wu, Xiujun Zhang, Yongxiang Wang, Yongxiang Wang, Jie Shi, Yumei Wang, Yumei Wang, Lin Lu, Xiangyou Li, Yanping Bao · 发表于：The Lancet Regional Health - Western Pacific · 年份：2024 · DOI：10.1016/j.lanwpc.2024.101086 · 被引用次数：19 · 研究领域：Long-Term Effects of COVID-19、Functional Brain Connectivity Studies、COVID-19 and Mental Health

Background: A variety of symptoms, particularly cognitive, psychiatric and neurological symptoms, may persist for a long time among individuals recovering from COVID-19. However, the underlying mechanism of these brain abnormalities remains unclear. This study aimed to investigate the long-term neuroimaging effects of COVID-19 infection on brain functional activities using resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Fifty-two survivors 27 months after infection (mild-moderate group: 25 participants, severe-critical: 27 participants), from our previous community participants, along with 35 healthy controls, were recruited to undergo fMRI scans and comprehensive cognitive function measurements. Participants were evaluated by subjective assessment of Cognitive Failures Questionnaire-14 (CFQ-14) and Fatigue Scale-14 (FS-14), and objective assessment of Montreal Cognitive Assessment (MoCA), N-back, and Simple Reaction Time (SRT). Each had rs-fMRI at 3T. Measures such as the amplitude of low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and regional homogeneity (ReHo) were calculated. Findings: Compared with healthy controls, survivors of mild-moderate acute symptoms group and severe-critical group had a significantly higher score of cognitive complains involving cognitive failure and mental fatigue. However, there was no difference of cognitive complaints between two groups of COVID-19 survivors. The performan...