Baicalin nanodelivery system based on functionalized metal-organic framework for targeted therapy of osteoarthritis by modulating macrophage polarization

作者：Lanli Huang, Yi Yao, Zhuren Ruan, Shengqing Zhang, Xianjing Feng, Chun‐Yi Lu, Jinmin Zhao, Feiying Yin, Cunwei Cao, Zheng Li · 发表于：Journal of Nanobiotechnology · 年份：2024 · DOI：10.1186/s12951-024-02494-5 · 被引用次数：49 · 研究领域：Flavonoids in Medical Research、Inflammatory mediators and NSAID effects、Oral microbiology and periodontitis research

Abstract Intra-articular drugs used to treat osteoarthritis (OA) often suffer from poor pharmacokinetics and stability. Nano-platforms as drug delivery systems for drug delivery are promising for OA therapy. In this study, we reported an M1 macrophage-targeted delivery system Bai@FA-UIO-66-NH 2 based on folic acid (FA) -modified metal-organic framework (MOF) loaded with baicalin (Bai) as antioxidant agent for OA therapy. With outstanding biocompatibility and high drug loading efficiency, Bai@FA-UIO-66-NH 2 could be specifically uptaken by LPS-induced macrophages to serve as a potent ROS scavenger, gradually releasing Bai at the subcellular level to reduce ROS production, modulate macrophage polarization to M2, leading to alleviation of synovial inflammation in OA joints. The synergistic effect of Bai@FA-UIO-66-NH 2 on macrophage polarization and ROS scavenging significantly improved the therapeutic efficacy of OA, which may provide a new insight into the design of OA precision therapy.