An adhesion-switchable hydrogel dressing for painless dressing removal without secondary damage

作者：Zhiling Yu, Weiqiang Huang, Wang Fei, Xuan Nie, Guang Chen, Lei Zhang, Ai-Zong Shen, Ze Zhang, Changhui Wang, Ye‐Zi You · 发表于：Journal of Materials Chemistry B · 年份：2024 · DOI：10.1039/d4tb00621f · 被引用次数：13 · 研究领域：Electrospun Nanofibers in Biomedical Applications、Surgical Sutures and Adhesives、Wound Healing and Treatments

-isopropyl acrylamide), quaternary ammonium chitosan and tannic acid. This hydrogel forms instant and robust adhesion to the skin at body temperature. However, as the temperature rises above the lower critical solution temperature (LCST), the hydrogel loses its adhesion towards the wound area due to the temperature-dependent volume phase transition of the copolymer, occurring around 45 °C. Consequently, the designed hydrogel can be easily detached from adhered tissues upon demand, providing a facile and effective method for painless dressing changes without secondary damage. This hydrogel holds great promise for long-term application in wound dressings.