Porin deficiency or plasmid copy number increase mediated carbapenem-resistant Escherichia coli resistance evolution

作者：Guoxiu Xiang, Zhiwei Zhao, Shebin Zhang, Yimei Cai, Yuting He, Jianming Zeng, Chen Cha, Bin Huang · 发表于：Emerging Microbes & Infections · 年份：2024 · DOI：10.1080/22221751.2024.2352432 · 被引用次数：13 · 研究领域：Antibiotic Resistance in Bacteria、Bacterial Genetics and Biotechnology、Escherichia coli research studies

D140Y (GAT→TAT) mutation. Bacterial hosts and conjugative plasmids can undergo resistance evolution under certain concentrations of antimicrobial pressure by reducing the expression of outer membrane proteins or increasing plasmid copy numbers.