CBTRUS Statistical Report: American Brain Tumor Association & NCI Neuro-Oncology Branch Adolescent and Young Adult Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016–2020

作者：Mackenzie Price, Corey Neff, Nitin Nagarajan, Carol Kruchko, Kristin Waite, Gino Cioffi, Brittany Cordeiro, Nicole E. Willmarth, Marta Peñas-Prado, Mark R. Gilbert, Terri S. Armstrong, Jill S. Barnholtz‐Sloan, Quinn T. Ostrom · 发表于：Neuro-Oncology · 年份：2024 · DOI：10.1093/neuonc/noae047 · 被引用次数：95 · 研究领域：Glioma Diagnosis and Treatment、Brain Metastases and Treatment、Acute Lymphoblastic Leukemia research

Recent analyses have shown that, whereas cancer survival overall has been improving, it has not improved for adolescents and young adults ages 15-39 years (AYA). The clinical care of AYA with primary brain and other central nervous system (CNS) tumors (BT) is complicated by the fact that the histopathologies of such tumors in AYA differ from their histopathologies in either children (ages 0-14 years) or older adults (ages 40+ years). The present report, as an update to a 2016 publication from the Central Brain Tumor Registry of the United States and the American Brain Tumor Association, provides in-depth analyses of the epidemiology of primary BT in AYA in the United States and is the first to provide biomolecular marker-specific statistics and prevalence by histopathology for both primary malignant and non-malignant BT in AYA. Between 2016 and 2020, the annual average age-specific incidence rate (AASIR) of primary malignant and non-malignant BT in AYA was 12.00 per 100,000 population, an average of 12,848 newly diagnosed cases per year. During the same period, an average of 1,018 AYA deaths per year were caused by primary malignant BT, representing an annual average age-specific mortality rate of 0.96 per 100,000 population. When primary BT were categorized by histopathology, pituitary tumors were the most common (36.6%), with an AASIR of 4.34 per 100,000 population. Total incidence increased with age overall; when stratified by sex, the incidence was higher in females than ...