Effects of Social Support on Medication Adherence Among Patients with Schizophrenia: Serial Multiple Mediation Model

作者：Nan Jiang, Wei Jin, Zhenghui Fu, He Cao, Hong Zheng, Quqing Wang, Qiongting Zhang, Kang Ju, Jiwei Wang · 发表于：Patient Preference and Adherence · 年份：2024 · DOI：10.2147/ppa.s460210 · 被引用次数：15 · 研究领域：Schizophrenia research and treatment、Family Caregiving in Mental Illness、Mental Health Treatment and Access

Purpose: This study aims to explore the serial mediating effect of stigma and depression on the association between social support and medication adherence. Patients and Methods: A cross-sectional survey was undertaken in the Changning District of Shanghai using a five-part questionnaire from August to December 2023. A convenient sampling method was employed, and 35 patients with schizophrenia were invited from each of the 9 streets in Changning District to participate in the survey, resulting in a total of 305 valid questionnaires collected. The questionnaire measured social support, stigma, depression, medication adherence, and demographic characteristics. Data analysis involved descriptive statistics, independent samples t-tests, ANOVA, Pearson correlation analysis, and the bootstrap method. Results: There was a direct and significantly positive association between social support and medication adherence (β = 0.69, p < 0.001). Moreover, increased levels of stigma (β = - 0.45, p = 0.013) and depression (β = - 0.09, p = 0.017) were both associated with a decline in medication adherence. Bootstrapping analysis revealed that the association between social support and medication adherence operated indirectly through stigma (β = 0.11, 95% CI: 0.03, 0.18). Additionally, social support was indirectly associated with medication adherence through depression (β = 0.15, 95% CI: 0.04, 0.30). Further analysis indicated that social support had an indirect association with medication adhe...