A novel neuroprotective peptide YVYAETY identified and screened from Flammulina velutipes protein hydrolysates attenuates scopolamine-induced cognitive impairment in mice

作者：Yutong Dong, Qiuhui Hu, Liyan Zhao, Gaoxing Ma, Ning Ma, Junmiao Zhang, Yang Ji, Li Liu · 发表于：Food & Function · 年份：2024 · DOI：10.1039/d4fo00871e · 被引用次数：12 · 研究领域：Genomics, phytochemicals, and oxidative stress、GDF15 and Related Biomarkers、Macrophage Migration Inhibitory Factor

. The behavioral tests showed that YVYAETY improved scopolamine-induced cognitive impairment in mice. YVYAETY also alleviated neuron damage including neuron vacuolation and pyknotic nuclei in the hippocampus. Furthermore, it significantly inhibited oxidative stress and suppressed the activation of the Nrf2 pathway. Therefore, this study revealed that YVYAETY had the potential to serve as a novel neuroprotective agent.