Association between gut microbiota dysbiosis and poor functional outcomes in acute ischemic stroke patients with COVID-19 infection

作者：Jiaying Chen, Xuxuan Gao, Jingru Liang, Qiheng Wu, Linlin Shen, Yifeng Zheng, Yu Ma, Yu-Ping Peng, Yan He, Jia Yin · 发表于：mSystems · 年份：2024 · DOI：10.1128/msystems.00185-24 · 被引用次数：11 · 研究领域：Long-Term Effects of COVID-19、Gut microbiota and health、Intensive Care Unit Cognitive Disorders

ABSTRACT Acute ischemic stroke (AIS) patients with active COVID-19 infection often have more severe symptoms and worse recovery. COVID-19 infection can cause gut microbiota dysbiosis, which is also a risk factor for poor outcomes in AIS patients. However, the association between gut microbiota and functional outcomes among AIS patients with COVID-19 infection has not been fully clarified yet. In this study, we performed 16S rRNA gene sequencing to characterize the gut microbial community among AIS patients with acute COVID-19 infection, AIS patients with post-acute COVID-19 infection, and AIS patients without COVID-19 infection. We found that AIS patients with acute COVID-19 experienced poorer recovery and significant gut dysbiosis, characterized by higher levels of Enterobacteriaceae and lower levels of Ruminococcaceae and Lachnospiraceae . Furthermore, a shorter time window (less than 28 days) between COVID-19 infection and stroke was identified as a risk factor for poor functional outcomes in AIS patients with COVID-19, and the enrichment of Enterobacteriaceae was indicated as a mediator in the relationship between infection time window and poor stroke outcomes. Our findings highlight the importance of early intervention after COVID-19 infection, especially by regulating the gut microbiota, which plays a role in the prognosis of AIS patients with COVID-19 infection. IMPORTANCE The gut microbiota plays an important role in the association between respiratory system and cere...