Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia

作者：Chunjie Xiang, Yixuan Sun, Yong Luo, Cong Xie, Weikun Huang, Karen L. Jones, Michael Horowitz, Zilin Sun, Christopher K. Rayner, Jianhua Ma, Tongzhi Wu · 发表于：Diabetes Obesity and Metabolism · 年份：2024 · DOI：10.1111/dom.15635 · 被引用次数：10 · 研究领域：Diet and metabolism studies、Diabetes Management and Research、Biochemical Analysis and Sensing Techniques

Abstract Aim To evaluate sex differences in gastric emptying and the glycaemic response to a glucose drink and a high carbohydrate meal in type 2 diabetes (T2D). Methods In cohort 1, 70 newly diagnosed, treatment‐naïve Chinese patients with T2D (44 men) recruited from a diabetes outpatient clinic ingested a 75‐g glucose drink containing 150 mg 13 C‐acetate. In cohort 2, 101 Australian patients with T2D (67 male) recruited from the community, managed by diet and/or metformin monotherapy, ingested a semi‐solid mashed potato meal, labelled with 100 μl 13 C‐octanoic acid. Breath samples were collected over 3 and 4 h, respectively, for assessment of gastric emptying, and venous blood was sampled for evaluation of glycaemia (with and without adjustment for each participant's estimated total blood volume). Results Gastric emptying was slower in female than male subjects in both cohorts (both p < .01). Multiple linear regression analyses revealed that gastric emptying was independently associated with sex (both p < .05). Without adjustment for blood volume, the glycaemic responses to oral glucose and the mixed meal were greater in female subjects (both p < .001). However, after adjustment for blood volume, the glycaemic responses were greater in men (both p < .05). Conclusions Gastric emptying is slower in women than men with T2D, associated with a reduced blood volume‐adjusted glycaemic response to oral glucose and a mixed meal in women. These observations highlight the ...