Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis

作者：Ariel A. Salas, Elizabeth Gunn, Waldemar A. Carlo, Edward F. Bell, Abhik Das, Cassandra D. Josephson, Ravi M. Patel, Sylvia Tan, Haresh Kirpalani, Richard A. Polin, Abbot R. Laptook, Martin Keszler, Angelita M. Hensman, Emily Little, Lucille St. Pierre, Elisa Vieira, Michele C. Walsh, Anna Maria Hibbs, Nancy S. Newman, Allison H. Payne, Deanne E. Wilson-Costello, Bonnie S. Siner, Monika Bhola, Gulgun Yalcinkaya, William E. Truog, Eugenia K. Pallotto, Howard W. Kilbride, Cheri Gauldin, Anne Holmes, Kathy Johnson, Allison Scott, Brenda B. Poindexter, Stephanie L. Merhar, Kurt Schibler, Cathy Grisby, Kristin Kirker, Sandra Wuertz, Lenora Jackson, Greg Muthig, Juanita Dudley, Robin K. Whyte, C. Michael Cotten, Ronald N. Goldberg, Ricki F. Goldstein, William Malcolm, Patricia L. Ashley, Deesha Mago-Shah, Mollie Warren, Joanne Finkle, Kimberley A. Fisher, Kathryn E. Gustafson, Matthew M. Laughon, Carl Bose, Janice Bernhardt, Janice Wereszczak, Diane Warner, Jennifer Talbert, Cindy Clark, Stephen D. Kicklighter, Alexandra Bentley, Laura Edwards, Ginger Rhodes-Ryan, Donna L. White, Ravi M. Patel, David P. Carlton, Barbara J. Stoll, Ira Adams‐Chapman, Yvonne Loggins, Ellen C. Hale, Diane I. Bottcher, Sheena L. Carter, Salathiel Kendrick-Allwood, Maureen Mulligan LaRossa, Colleen Mackie, Gloria V. Smikle, Lynn C. Comerford, Rosemary D. Higgins, Andrew A. Bremer, Stephanie Wilson Archer, Gregory M. Sokol, Heidi M. Harmon, L.A. Papile, Abbey C. Hines, Dianne E. Herron, Susan Gunn, Lucy Smiley, Jeff Joyce, John A. F. Zupancic, Kathleen A. Kennedy, Jon E. Tyson, Amir Khan, Julie Arldt-McAlister, Elizabeth Eason, Carmen Garcia, Donna J. Hall, Karen Martin, Georgia E. McDavid, Shawna Rodgers, Emily K. Stephens, Sharon L. Wright, Traci Heath Mondoro, Catherine Levy, Pablo J. Sánchez, Leif D. Nelin, Nathalie L. Maitre, Ruth Seabrook, Sudarshan R. Jadcherla, Patricia Luzader, Christine A. Fortney, Julie Gutentag, Christopher J. Timan, Kristi Small, Rox Ann Sullivan, Lina Yoseff-Salameh, Jacqueline McCool, Melanie Stein, Erin Fearns, Aubrey Fowler, Jennifer L. Grothause, Stephanie Burkhardt, Jessica Purnell, Mary Ann Nelin, Helen Carey, Lindsay Pietruszewski, Margaret Sullivan, Julie C. Shadd, Jennifer L. Notestine, Cole Hague, Erna Clark, Michelle Chao, Courtney Park, Hallie Baugher, Demi R. Beckford, Bethany Miller, Laura Marzec, Kyrstin Warnimont, Carla Bann, Marie G. Gantz, Donald Brambilla, Jamie E. Newman, Jenna Gabrio, Margaret M. Crawford, Carolyn M. Petrie Huitema, Jeanette O’Donnel Auman, David LeBlond, Annie M. VonLehmden, Dennis Wallace, Kristin M. Zaterka-Baxter, Krisa P. Van Meurs, David K. Stevenson, Susan R. Hintz, M. Bethany Ball, Valerie Y. Chock, Barbara Bentley, Maria Elena DeAnda, Anne M. DeBattista, Beth Earhart, Lynne C. Huffman, Casey E. Krueger, Ryan E. Lucash, Melinda S. Proud, Elizabeth N. Reichert, Heather Taylor, Hali E. Weiss, Namasivayam Ambalavanan, Monica V. Collins, Shirley S. Cosby, Myriam Peralta Carcelen, Fred J. Biasini, Kristen C. Johnston, Mary Beth Moses, Tara E. McNair, Vivien A. Phillips, Richard V. Rector, Sally Whitley, Kristy A. Domnanovich, Sheree York Chapman, Uday Devaskar, Meena Garg, Isabell B. Purdy, Teresa Chanlaw, Rachel Geller, Tarah T. Colaizy, Jane E. Brumbaugh, John A. Widness, Heidi M. Harmon, Karen Johnson, Jacky R. Walker, Claire A. Goeke, Diane L. Eastman, Kristi L. Watterberg, Robin K. Ohls, Conra Backstrom Lacy, Janell Fuller, Mary Hanson, Carol Hartenberger, Elizabeth Kuan, Jean Lowe, Sandra Sundquist Beauman, Barbara Schmidt, Sara B. DeMauro, Soraya Abbasi, Toni Mancini, Dana M. Cucinotta, Jonathan Snyder, Aasma S. Chaudhary, Carl T. D’Angio, Ronnie Guillet, Melissa F. Carmen, Gary J. Myers, Kyle Binion, Caitlin Fallone, Osman Farooq, Julianne Hunn, Rosemary L. Jensen, Joan Merzbach, Constance Orme, Ann Marie Scorsone, Holly I.M. Wadkins, Kelley Yost, Satyan Lakshminrusimha, Anne Marie Reynolds, Stephanie Guilford, Michelle E. Hartley-McAndrews, Ashley Williams, William Zorn, Mary Rowan, Dee Maffett, Diane Prinzing, Melissa Bowman, Michael Sacilowski, Daisy Rochesz, Myra H. Wyckoff, Luc P. Brion, Roy J. Heyne, Diana M. Vasil, Sally S. Adams, Maria Magdalena Leon, Frances Eubanks, Alicia Guzman, Elizabeth T. Heyne, Lizette E. Lee, Linda A. Madden, Lara Pavageau, Pollieanna Sepulveda, Cathy Twell Boatman, Kristine Tolentino-Plata, Bradley A. Yoder, Mariana Baserga, Stephen D. Minton, Mark J. Sheffield, Carrie A. Rau, Jill Burnett, Susan Christensen, Laura Cole Bledsoe, Jennifer O. Elmont, Trisha Marchant, Earl Maxson, Kandace M. McGrath, Hena G. Mickelsen, Dilys M. Parry, Brixen A. Reich, Susan T. Schaefer, Kimberlee Weaver-Lewis, Kathryn D. Woodbury, Seetha Shankaran, Beena G. Sood, Sanjay Chawla, Rebecca Bara, Prashant Agarwal, Monika Bajaj, Kirsten Childs, Melissa February, Laura A. Goldston, Mary E. Johnson, Girija Natarajan, Bogdan Panaitescu, Eunice Woldt, John Barks, Martha Carlson, Diane F. White · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2024.9643 · 被引用次数：15 · 研究领域：Blood transfusion and management、Neonatal Health and Biochemistry、Infant Nutrition and Health

Importance: Observational studies often report that anemia and red blood cell (RBC) transfusions are associated with a higher risk of necrotizing enterocolitis (NEC) among extremely low-birthweight (ELBW) infants. Objective: To evaluate whether there is a temporal association between 72-hour hazard periods of exposure to RBC transfusions and NEC among ELBW infants randomized to either higher or lower hemoglobin transfusion thresholds. Design, Setting, and Participants: This post hoc secondary analysis of 1690 ELBW infants who survived to postnatal day 10 enrolled in the Transfusion of Prematures (TOP) randomized multicenter trial between December 1, 2012, and April 12, 2017, was performed between June 2021 and July 2023. Exposures: First, the distribution of RBC transfusions and the occurrence of NEC up to postnatal day 60 were examined. Second, 72-hour posttransfusion periods were categorized as hazard periods and the pretransfusion periods of variable duration as control periods. Then, the risk of NEC in posttransfusion hazard periods was compared with that in pretransfusion control periods, stratifying the risk based on randomization group (higher or lower hemoglobin transfusion threshold group). Main Outcomes and Measures: The primary outcome was incidence of NEC stage 2 or 3. Secondary outcomes included the incidence rates of NEC within five 10-day intervals, taking into account the number of days at risk. Results: Of 1824 ELBW infants randomized during the TOP trial, 16...