Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients

作者：Justin Z. Wang, Alexander Landry, David Ronan Raleigh, Felix Sahm, Kyle M. Walsh, Roland Goldbrunner, Leeor S. Yefet, Jörg Christian Tonn, Chloe Gui, Quinn T. Ostrom, Jill S. Barnholtz‐Sloan, Arie Perry, Yosef Ellenbogen, Clemens Oliver Hanemann, Gerhard Jungwirth, Michael D. Jenkinson, Ghazaleh Tabatabai, Tiit Illimar Mathiesen, Michael William McDermott, Marcos Soares Tatagiba, Christian la Fougère, Sybren L. N. Maas, Norbert Galldiks, Nathalie L. Albert, Priscilla Kaliopi Brastianos, Felix Ehret, Giuseppe Caracciolo Minniti, Katrin Lamszus, Franz Lennard Ricklefs, Jens Schittenhelm, Katharine Jann Drummond, Ian F. Dunn, Omar Nathan Pathmanaban, Aaron Cohen‐Gadol, Erik P. Sulman, Émeline Tabouret, Emelie Le Rhun, Christian Mawrin, Jennifer A. Moliterno, Michael Weller, Wenya Linda Bi, Andrew F. Gao, Stephen S. F. Yip, Maximilian Niyazi, Kenneth Aldape, Patrick Yung Wen, Susan C Short, Matthias Preusser, Farshad Nassiri, Gelareh Mohammed Zadeh · 发表于：Neuro-Oncology · 年份：2024 · DOI：10.1093/neuonc/noae082 · 被引用次数：153 · 研究领域：Meningioma and schwannoma management、Neurofibromatosis and Schwannoma Cases、Head and Neck Surgical Oncology

Meningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and increased access to neuroimaging. While most exhibit nonmalignant behavior, a subset of meningiomas are biologically aggressive and are associated with treatment resistance, resulting in significant neurologic morbidity and even mortality. In recent years, meaningful advances in our understanding of the biology of these tumors have led to the incorporation of molecular biomarkers into their grading and prognostication. However, unlike other central nervous system (CNS) tumors, a unified molecular taxonomy for meningiomas has not yet been established and remains an overarching goal of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-Not Official World Health Organization (cIMPACT-NOW) working group. Additionally, clinical equipoise still remains on how specific meningioma cases and patient populations should be optimally managed. To address these existing gaps, members of the International Consortium on Meningiomas including field-leading experts, have prepared this comprehensive consensus narrative review directed toward clinicians, researchers, and patients. Included in this manuscript are detailed overviews of proposed molecular classifications, novel biomarkers, contemporary treatment strategies, trials on systemic therapies, health-related quality-of-life studies, and management strategies for unique meningi...