Morphological Engineering of Filamentous Fungi: Research Progress and Perspectives

作者：Zhengwu Lu, Zhiqun Chen, Yun‐Guo Liu, Xuexue Hua, Cuijuan Gao, Jingjing Liu · 发表于：Journal of Microbiology and Biotechnology · 年份：2024 · DOI：10.4014/jmb.2402.02007 · 被引用次数：31 · 研究领域：Microbial Metabolic Engineering and Bioproduction、Slime Mold and Myxomycetes Research、Fungal Biology and Applications

the food, textile, medical, and chemical industries and have great commercial application value [4,5].For example, filamentous fungi, especially Ascomycetes and Basidiomycetes, are known to produce an extraordinary range of colors, including several chemical classes of pigments, such as melanins, azaphilones, flavins, phenazines, and quinines [6].Compared to other conventional sources, industry is more focused on filamentous fungi, which can be easily grown in the laboratory and provide the possibility of large-scale production [7].Filamentous fungi can secrete a wide variety and large amounts of enzymes, including glycosylases, proteases, phytases, pectinases, and peroxidases [8-10], which can degrade polymers in organic wastes, such as (hemi)cellulose and starch, into small molecules as energy and carbon sources.Thus, filamentous fungi also play an important role in nature by degrading organic wastes [11,12].The enormous secretion capacity of fungi has already been used by industry for decades to produce organic acids and polymers, represented by citric acid, polylactic acid, gluconic acid, itaconic acid and lactic acid, as potential alternatives to petroleum-based plastics or raw materials [13].Of these, citric acid has been commercially produced using Aspergillus niger for almost a century, generating significant economic value [14].In addition, filamentous fungi are productive strains of some important antibiotics, such as penicillin [15].Thus, filamentous fungi have wid...