Nickel-Catalyzed Enantioselective Reductive Arylation of Common Ketones

作者：Shuai Huang, Jianrong Steve Zhou · 发表于：Journal of the American Chemical Society · 年份：2024 · DOI：10.1021/jacs.4c02818 · 被引用次数：42 · 研究领域：Catalytic C–H Functionalization Methods、Asymmetric Hydrogenation and Catalysis、Asymmetric Synthesis and Catalysis

A nickel complex of chiral bisoxazolines catalyzed the stereoselective reductive arylation of ketones in high enantioselectivity. A range of common acyclic and cyclic ketones reacted without the aid of directing groups. Mechanistic studies using isolated complex of a chiral bis(oxazoline) (L)Ni(Ar)Br revealed that Mn reduction was not needed, while Lewis acidic titanium alkoxides were critical to ketone insertion.