Role of Microbiome in Personalized Medicine

作者：Sami Siraj · 发表于：Precision Medicine Communications · 年份：2023 · DOI：10.55627/pmc.003.02.0480 · 被引用次数：4 · 研究领域：Gut microbiota and health

The human microbiome, which consists of trillions of microorganisms residing in and on the human body, plays a significant role in personalized medicine. The microbiome has been recognized as a critical factor influencing various aspects of health and disease, and its consideration in personalized medicine is expanding. Factors such as genetics, diet, environment, and lifestyle contribute to the unique microbial profile of each person. Therefore, the microbiome varies between individuals in terms of its composition and diversity. The microbiome can influence drug metabolism and response. Some drugs undergo biotransformation by gut bacteria, affecting the pharmacokinetics and efficacy of the drugs. Understanding an individual's microbiome may help predict and optimize drug responses. The microbiome also plays a crucial role in shaping the immune system. Imbalances or dysbiosis in the microbiome have been linked to various immune-related disorders. Considering the microbiome in the development of immunotherapies and treatments for autoimmune diseases would help in developing personalized medicine. The bidirectional communication between the gut and the brain, known as the gut-brain axis, is influenced by the microbiome. The gut microbiome may impact neurological conditions, mental health, and even responses to certain medications. Personalized approaches may consider the gut-brain axis in neurological and psychiatric disorders. Similarly, alterations in the microbiome have been...