Highly stretchable and customizable microneedle electrode arrays for intramuscular electromyography

作者：Qinai Zhao, Ekaterina Gribkova, Yiyang Shen, Jilai Cui, Noel Naughton, Liangshu Liu, Jaemin Seo, Baixin Tong, Mattia Gazzola, Rhanor Gillette, Hangbo Zhao · 发表于：Science Advances · 年份：2024 · DOI：10.1126/sciadv.adn7202 · 被引用次数：73 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Muscle activation and electromyography studies、Neuroscience and Neural Engineering

Stretchable three-dimensional (3D) penetrating microelectrode arrays have potential utility in various fields, including neuroscience, tissue engineering, and wearable bioelectronics. These 3D microelectrode arrays can penetrate and conform to dynamically deforming tissues, thereby facilitating targeted sensing and stimulation of interior regions in a minimally invasive manner. However, fabricating custom stretchable 3D microelectrode arrays presents material integration and patterning challenges. In this study, we present the design, fabrication, and applications of stretchable microneedle electrode arrays (SMNEAs) for sensing local intramuscular electromyography signals ex vivo. We use a unique hybrid fabrication scheme based on laser micromachining, microfabrication, and transfer printing to enable scalable fabrication of individually addressable SMNEA with high device stretchability (60 to 90%). The electrode geometries and recording regions, impedance, array layout, and length distribution are highly customizable. We demonstrate the use of SMNEAs as bioelectronic interfaces in recording intramuscular electromyography from various muscle groups in the buccal mass of Aplysia .