Hypo-connectivity of the primary somatosensory cortex in Parkinson’s disease: a resting-state functional MRI study

作者：Yinghua Wang, Tao Gong, Tao Na, Ying Zeng, Haotian Ma, Wu Yuan, Wenmin Luo, Fuqing Zhou · 发表于：Frontiers in Neurology · 年份：2024 · DOI：10.3389/fneur.2024.1361063 · 被引用次数：2 · 研究领域：Neurological disorders and treatments、Functional Brain Connectivity Studies、Transcranial Magnetic Stimulation Studies

Background: Parkinson's disease (PD) is characterized by a range of motor symptoms as well as documented sensory dysfunction. This sensory dysfunction can present itself either as a "pure" sensory disturbance or as a consequence of sensory-motor integration within the central nervous system. This study aims to investigate changes in the functional connectivity of the primary somatosensory cortex (S1) and its clinical significance in Parkinson's disease (PD), an area that has received limited attention in previous neuroimaging studies. Methods: This study included thirty-three patients with PD and thirty-four healthy controls (HCs). Clinical evaluations were conducted to assess the clinical manifestations, severity, and functional capacity of all the patients. Resting-state functional MRI (fMRI) was employed to evaluate the functional connectivity of six paired S1 subregions in the participants. Seed-based correlation (SBC) analysis was utilized to construct the correlation matrix among the subregions and to generate connectivity maps between the subregions and the remaining brain voxels. Finally, the study employed partial least-squares (PLS) correlation analysis to investigate the association between modified functional connectivity and clinical characteristics in PD patients. Results: < 0.001, corrected for false discovery rate) and in the default mode network (DMN) as distinct patterns. Moreover, this study identified a negative association between the correlation matrix w...