Altered coordination between sleep timing and cortisol profiles in night working female hospital employees

作者：Katarzyna Burek, Sylvia Rabstein, Thomas Kantermann, Céline Vetter, Rui Wang‐Sattler, Martin Lehnert, Dirk Pallapies, Karl‐Heinz Jöckel, Thomas Brüning, Thomas Behrens · 发表于：Psychoneuroendocrinology · 年份：2024 · DOI：10.1016/j.psyneuen.2024.107066 · 被引用次数：6 · 研究领域：Sleep and Work-Related Fatigue、Sleep and related disorders、Stress Responses and Cortisol

BACKGROUND: Cortisol typically peaks in the morning after waking up and declines throughout the day, reaching its lowest levels during nighttime sleep. Shift work can cause misalignment between cortisol levels and sleep-wake timing. We analyzed this misalignment in female shift workers focusing on the timing and extent of these changes. METHODS: We conducted a cross-sectional study involving 68 shift workers (aged 37 ± 10 years) and 21 non-shift workers (aged 45 ± 10 years) from a hospital. Shift workers were monitored through two day shifts and three night shifts, whereas non-shift workers were monitored during two day shifts. Each participant collected six to eight saliva samples (depending on their shift type) and provided sleep timing information, which was recorded via polysomnography and sleep diaries. Generalized additive mixed models were used to estimate shift-specific differences in cortisol smooth curves. Summary measures calculated for the cortisol smooth curves included cortisol awakening response, peak-to-bed slope, and total output. RESULTS: Between shift workers and non-shift workers, we observed similar diurnal cortisol profiles with a steep negative diurnal slope during day shifts. In shift workers on night shifts, a flattened U-shaped cortisol profile after the post-awakening maximum was observed, with a peak-to-bed slope close to zero. When comparing night to day shifts in the group of shift workers, mean cortisol levels were lower between 42 and 56 minute...