Neuroprotective effects of dantrolene in neurodegenerative disease: Role of inhibition of pathological inflammation

作者：Wenjia Zhang, Xu Zhao, Piplu Bhuiyan, Henry Liu, Huafeng Wei · 发表于：Journal of Anesthesia and Translational Medicine · 年份：2024 · DOI：10.1016/j.jatmed.2024.04.002 · 被引用次数：11 · 研究领域：Neuroscience and Neuropharmacology Research、Neuroinflammation and Neurodegeneration Mechanisms、Tryptophan and brain disorders

Neurodegenerative diseases (NDs) refer to a group of diseases in which slow, continuous cell death is the main pathogenic event in the nervous system. Most NDs are characterized by cognitive dysfunction or progressive motor dysfunction. Treatments of NDs mainly target alleviating symptoms, and most NDs do not have disease-modifying drugs. The pathogenesis of NDs involves inflammation and apoptosis mediated by mitochondrial dysfunction. Dantrolene, approved by the US Food and Drug Administration, acts as a RyRs antagonist for the treatment of malignant hyperthermia, spasticity, neuroleptic syndrome, ecstasy intoxication and exertional heat stroke with tolerable side effects. Recently, dantrolene has also shown therapeutic effects in some NDs. Its neuroprotective mechanisms include the reduction of excitotoxicity, apoptosis and neuroinflammation. In summary, dantrolene can be considered as a potential therapeutic candidate for NDs.