Sucrose‐Powered Liposome Nanosensors for Urinary Glucometer‐Based Monitoring of Cancer

作者：Dongtao Zhou, Zhibin Zhang, Liqing Pan, Yanyi Wang, Jingjing Yang, Yanfeng Gao, Yujun Song · 发表于：Angewandte Chemie International Edition · 年份：2024 · DOI：10.1002/anie.202404493 · 被引用次数：19 · 研究领域：Advanced biosensing and bioanalysis techniques、Molecular Communication and Nanonetworks、Nanoplatforms for cancer theranostics

Timely detection of early-stage cancer holds immense potential in enhancing prognostic outcomes. There is an increasing desire for versatile tools to enable simple, sensitive, and cost-effective cancer detection. By exploiting the extraintestinal metabolic inertness and efficiency renal clearance of sucrose, we designed a liposome nanosensor using sucrose as a messenger to convert tumor-specific esterase activity into glucose meter readout, enabling economical and sensitive urinalysis for cancer detection in point-of-care testing (POCT). Our results demonstrate that the nanosensors exhibited significant signal differences between tumor-bearing and healthy mice in both orthotopic and metastatic tumor models. Additionally, efficient elimination of the nanosensors through the hepatobiliary pathway was observed with no significant toxicity. Such a non-invasive diagnostic modality significantly assists in personalized pharmacological treatment and follow-up efficacy assessment. We envision that this modular liposome nanosensor platform might be applied for economically detecting diverse diseases via a simple urinary test.