TFA-Mediated Synthesis of 1,2,4-Oxadiazoles from Carbamates and Nitriles

作者：Daijiao Zhuang, Yuankun Wu, Shuairan Wang, Yuelin Tao, Peihua Liu, Xiaofeng Luo, Tianqiang Wang, Rulong Yan · 发表于：The Journal of Organic Chemistry · 年份：2024 · DOI：10.1021/acs.joc.4c00640 · 被引用次数：5 · 研究领域：Synthesis and Biological Evaluation、Catalytic C–H Functionalization Methods、Structural and Chemical Analysis of Organic and Inorganic Compounds

An unprecedented protocol for the synthesis of 1,2,4-oxadiazoles from carbamates has been developed by employing nitriles as both substrates and solvents. This one-pot procedure achieves the formation of C═N bonds via TFA-mediated [3+2] annulation. A series of 1,2,4-oxadiazoles are synthesized in moderate to good yields.