Unveiling the chemical complexity of food-risk components: A comprehensive data resource guide in 2024

作者：Dachuan Zhang, Dongliang Liu, Jiayi Jing, Bingxuan Jia, Ye Tian, Yingying Le, Yaochun Yu, Qian‐Nan Hu · 发表于：Trends in Food Science & Technology · 年份：2024 · DOI：10.1016/j.tifs.2024.104513 · 被引用次数：16 · 研究领域：Identification and Quantification in Food、Food Safety and Hygiene、Computational Drug Discovery Methods

With the influence of climate change, environmental pollution, industrial development, and new agricultural practices, increasing amounts of chemical substances with potential risks—both anthropogenic and biogenic—enter the food supply chain and ultimately affect human health, entailing new challenges to food safety and security. Although some food-risk components (FRCs) have been accessed and regulated, the toxicity and exposure level of the numerous components detected in food remain unknown, leaving questions on their effect on food safety. Therefore, multiple databases on emerging FRCs have been constructed to aid in food safety risk assessment, regulation, and communication; however, their focus areas, data content, quality, and accessibility have not been systematically summarized, which hinders the development and applications of data-driven methods in the food safety field. The major objective of this review is to comprehensively introduce representative FRC databases with different focus areas, along with their chemical presentation, data quality and availability, and successful applications. Over the past decades, over 50 FRC databases have been released and widely used in hazard identification, toxicity prediction, and exposure assessment, contributing significantly to scientific research, policymaking, and education. However, our analysis unveils persistent challenges such as delayed updates, accessibility concerns, reproducibility issues, suboptimal data quality,...