Recent advances in synergistic use of GQD-based hydrogels for bioimaging and drug delivery in cancer treatment

作者：Muhammad Hussnain Akmal, Masoomeh Yari Kalashgrani, Seyyed Mojtaba Mousavi, Vahid Rahmanian, Neha Sharma, Ahmad Gholami, Raed H. Althomali, Mohammed M. Rahman, Wei‐Hung Chiang · 发表于：Journal of Materials Chemistry B · 年份：2024 · DOI：10.1039/d4tb00024b · 被引用次数：34 · 研究领域：Carbon and Quantum Dots Applications、Supramolecular Self-Assembly in Materials、Graphene and Nanomaterials Applications

Graphene quantum dot (GQD) integration into hydrogel matrices has become a viable approach for improving drug delivery and bioimaging in cancer treatment in recent years. Due to their distinct physicochemical characteristics, graphene quantum dots (GQDs) have attracted interest as adaptable nanomaterials for use in biomedicine. When incorporated into hydrogel frameworks, these nanomaterials exhibit enhanced stability, biocompatibility, and responsiveness to external stimuli. The synergistic pairing of hydrogels with GQDs has created new opportunities to tackle the problems related to drug delivery and bioimaging in cancer treatment. Bioimaging plays a pivotal role in the early detection and monitoring of cancer. GQD-based hydrogels, with their excellent photoluminescence properties, offer a superior platform for high-resolution imaging. The tunable fluorescence characteristics of GQDs enable real-time visualization of biological processes, facilitating the precise diagnosis and monitoring of cancer progression. Moreover, the drug delivery landscape has been significantly transformed by GQD-based hydrogels. Because hydrogels are porous, therapeutic compounds may be placed into them and released in a controlled environment. The large surface area and distinct interactions of graphene quantum dots (GQDs) with medicinal molecules boost loading capacity and release dynamics, ultimately improving therapeutic efficacy. Moreover, GQD-based hydrogels' stimulus-responsiveness allows fo...