Cardiovascular mortality risk in patients with ovarian cancer: a population-based study

作者：Zelin Hu, Yingxue Yuan, Meng-Yi Xia, Ying Li, Ying Yang, Shengnan Wang, Xuanzhu Meng, Mo-Ying Sun, Ning Wang · 发表于：Journal of Ovarian Research · 年份：2024 · DOI：10.1186/s13048-024-01413-4 · 被引用次数：5 · 研究领域：Chemotherapy-induced cardiotoxicity and mitigation、Ovarian cancer diagnosis and treatment、Cancer, Lipids, and Metabolism

OBJECTIVES: Ovarian cancer (OC) can occur at different ages and is affected by a variety of factors. In order to evaluate the risk of cardiovascular mortality in patients with ovarian cancer, we included influencing factors including age, histological type, surgical method, chemotherapy, whether distant metastasis, race and developed a nomogram to evaluate the ability to predict occurrence. At present, we have not found any correlation studies on cardiovascular death events in patients with ovarian cancer. This study was designed to provide targeted measures for effective prevention of cardiovascular death in patients with ovarian cancer. METHODS: Kaplan-Meier analysis and multivariable Cox proportional model were performed to evaluate the effectiveness of cardiovascular diseases on overall survival (OS) and ovarian cancer-specific survival (OCSS). We compared multiple groups including clinical, demographic, therapeutic characteristics and histological types. Cox risk regression analysis, Kaplan-Meier survival curves, and propensity score matching were employed for analyzing the data. RESULTS: A total of 88,653 ovarian cancer patients were collected, of which 2,282 (2.57%) patients died due to cardiovascular-related diseases. Age, chemotherapy and whether satisfactory cytoreduction surgery is still the most important factors affecting the prognosis of ovarian cancer patients, while different histological types, diagnosis time, and race also have a certain impact on the progno...