Copper-Catalyzed Chemoselective Coupling of N-Dithiophthalimides and Alkyl Halides: Synthesis of Unsymmetrical Disulfides and Sulfides

作者：Bin Li, Bo-Xi Liu, Weidong Rao, Shusu Shen, Daopeng Sheng, Shun‐Yi Wang · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c01109 · 被引用次数：19 · 研究领域：Sulfur-Based Synthesis Techniques、Chemical Synthesis and Reactions、Synthesis and Catalytic Reactions

In this paper, we report an unprecedented copper-catalyzed disulfides or sulfides coupling reaction involving unactivated alkyl halides and N -dithiophthalimides. This reaction can be conducted under mild conditions using low-cost metal catalysts and exhibits high chemical selectivity and functional group compatibility, enabling the efficient assembly of various sulfides and disulfides.