Efficient Functionalization of Organosulfones via Photoredox Catalysis: Direct Incorporation of α-Carbonyl Alkyl Side Chains into α-Allyl-β-Ketosulfones

作者：Hong‐Li Huang, Shan Li, Yong-Zheng Lv, Ya‐Qian Shi, Tiantian Pang, Rufen Zhang, Wenjing Huang, Jianhui Yin, Fei Gao · 发表于：Molecules · 年份：2024 · DOI：10.3390/molecules29091971 · 被引用次数：4 · 研究领域：Sulfur-Based Synthesis Techniques、Chemical Synthesis and Reactions、Radical Photochemical Reactions

A novel and efficient method for functionalizing organosulfones has been established, utilizing a visible-light-driven intermolecular radical cascade cyclization of α-allyl-β-ketosulfones. This process employs fac-Ir(ppy)3 as the photoredox catalyst and α-carbonyl alkyl bromide as the oxidizing agent. Via this approach, the substrates experience intermolecular addition of α-carbonyl alkyl radicals to the alkene bonds, initiating a sequence of C-C bond formations that culminate in the production of organosulfone derivatives. Notably, this technique features gentle reaction conditions and an exceptional compatibility with a wide array of functional groups, making it a versatile and valuable addition to the field of organic synthesis.